Effect of mechanical loading on insulin-like growth factor-I gene expression in rat tibia.

@article{Reijnders2007EffectOM,
  title={Effect of mechanical loading on insulin-like growth factor-I gene expression in rat tibia.},
  author={Christianne M. A. Reijnders and Nathalie Bravenboer and Annechien M Tromp and Marinus A. Blankenstein and P J A Lips},
  journal={The Journal of endocrinology},
  year={2007},
  volume={192 1},
  pages={
          131-40
        }
}
Mechanical loading plays an essential role in maintaining skeletal integrity. Mechanical stimulation leads to increased bone formation. However, the cellular and molecular mechanisms that are involved in the translation of mechanical stimuli into bone formation, are not completely understood. Growth factors and osteocytes, which act as mechanosensors, play a key role during the bone formation after mechanical stimulation. The aim of this study was to characterize the role of IGF-I in the… CONTINUE READING

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