Effect of mazindol administration on (3H)-N-methylscopolamine binding to rat cerebral cortex.

@article{Viana1992EffectOM,
  title={Effect of mazindol administration on (3H)-N-methylscopolamine binding to rat cerebral cortex.},
  author={Glauce S B Viana and Francisca Cl{\'e}a F Sousa and Mar{\'i}a Manuela Marinho},
  journal={Life sciences},
  year={1992},
  volume={50 8},
  pages={
          549-53
        }
}
Mazindol has been shown to produce anorexia in several animal species including humans, and its pharmacological effects may be elicited by blockade of neuronal reuptake of dopamine and norepinephrine. Chronic treatment of rats with mazindol (10 mg/kg daily, p.o.) caused an increase in muscarinic receptor density (Bmax = 874.7 femtomoles/mg protein) as compared to controls (Bmax = 629.1 femtomoles/mg protein) in the cerebral motor cortex. An increase in dissociation constant (Kd) values was also… CONTINUE READING