Effect of maximum-tolerated doses and low-dose metronomic chemotherapy on serum vascular endothelial growth factor and thrombospondin-1 levels in patients with advanced nonsmall cell lung cancer

@article{Tas2007EffectOM,
  title={Effect of maximum-tolerated doses and low-dose metronomic chemotherapy on serum vascular endothelial growth factor and thrombospondin-1 levels in patients with advanced nonsmall cell lung cancer},
  author={Faruk Tas and Derya Duranyildiz and Hilal Oğuz Soydinç and Irfan Cicin and Meltem Topalgokceli Selam and Kazim Uygun and Rian Dişçi and Vildan Yasasever and Erkan Topuz},
  journal={Cancer Chemotherapy and Pharmacology},
  year={2007},
  volume={61},
  pages={721-725}
}
Angiogenesis is regulated by a balance of both angiogenic inducers and inhibitors. This study was designed to evaluate the effect of both maximum-tolerated doses (MTD) and low-dose metronomic chemotherapy (LDM) on serum vascular endothelial growth factor (VEGF), thrombospondin-1 (TSP1) and VEGFR1 concentrations in patients with advanced nonsmall cell lung cancer. Forty consecutive patients with advanced stage nonsmall cell lung cancer were included in this prospective study. Twenty patients… CONTINUE READING

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