Effect of maternal nutrient restriction in early gestation on development of the hypothalamic-pituitary-adrenal axis in fetal sheep at 0.8-0.9 of gestation.

@article{Hawkins1999EffectOM,
  title={Effect of maternal nutrient restriction in early gestation on development of the hypothalamic-pituitary-adrenal axis in fetal sheep at 0.8-0.9 of gestation.},
  author={Paul Hawkins and C. W Steyn and H H Mcgarrigle and Toshikazu Saito and Takeshi Ozaki and Lisa Stratford and David E Noakes and Mark A. Hanson},
  journal={The Journal of endocrinology},
  year={1999},
  volume={163 3},
  pages={553-61}
}
The fetal hypothalamic-pituitary-adrenal (HPA) axis has numerous key roles in development. Epidemiological data have linked adverse prenatal nutrition with altered organ development and increased incidence of disease in adult life. We studied HPA axis development in resting and stimulated states in late gestation fetal sheep, following 15% reduction in maternal nutritional intake over the first 70 days of gestation (dGA). Fetuses from control (C) and nutrient-restricted (R) ewes were… CONTINUE READING