Effect of maternal age on autosomal trisomies

@article{Hassold1980EffectOM,
  title={Effect of maternal age on autosomal trisomies},
  author={T. Hassold and P. Jacobs and J. Kline and Z. Stein and D. Warburton},
  journal={Annals of Human Genetics},
  year={1980},
  volume={44}
}
The effect of maternal age on the genesis of trisomy was studied by comparing data from 362 trisomic and 790 chromosomally normal spontaneous abortions. As a group the trisomies were associated with a substantial increase in maternal age but there were considerable differences in the magnitude of the effect for different trisomies. The effect of increasing maternal age was most pronounced for trisomies involving the small chromosomes, both acrocentric and non‐acrocentric. However, trisomy 16… Expand
77 Citations
Maternal age in trisomy
  • 48
Maternal-age effect in aneuploidy: does altered embryonic selection play a role?
  • 90
  • Highly Influenced
The origin of human trisomy: a study of heteromorphisms and satellite associations
  • 40
Parental age and the origin of trisomy 21
  • 7
Fetal death rates in mothers of children with trisomy 21 (Down syndrome)
  • 15
A cytogenetic study of 1000 spontaneous abortions
  • 602
On the parental origin of de novo mutation in man.
  • A. Chandley
  • Biology, Medicine
  • Journal of medical genetics
  • 1991
  • 118
  • PDF
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 21 REFERENCES
Sex chromosome aneuploidy and parental age
  • 38
Origin of the extra chromosome in trisomy 16
  • 25
A cytogenetic study of spontaneous abortions in Hawaii
  • 81
Chiasma Frequency and Maternal Age in Mammals
  • 431
Maternal age and the incidence of aneuploidy in first-cleavage mouse embryos.
  • 41
  • PDF
Chiasmata, meiotic univalents, and age in relation to aneuploid imbalance in mice.
  • 105
...
1
2
3
...