Effect of marginal ascorbic acid deficiency on saliva level of cortisol in the guinea pig.

@article{Enwonwu1995EffectOM,
  title={Effect of marginal ascorbic acid deficiency on saliva level of cortisol in the guinea pig.},
  author={Cyril O. Enwonwu and P G Sawiris and N P Chanaud},
  journal={Archives of oral biology},
  year={1995},
  volume={40 8},
  pages={737-42}
}
Male guinea pigs subjected to prolonged marginal ascorbic acid deficiency developed moon facies and oedema, features of functional adrenal hypercorticism. Compared with age- and sex-matched controls fed an adequate diet for a similar period, ascorbate deficiency had no effect on submandibular gland weight but elicited a significant (p < 0.005) reduction in stimulated whole-saliva flow rate. Plasma cortisol concentration (nmol/L) was significantly increased (p < 0.005) in the deficient animals… CONTINUE READING