Effect of maraviroc on the pharmacokinetics of midazolam, lamivudine/zidovudine, and ethinyloestradiol/levonorgestrel in healthy volunteers.

@article{Abel2008EffectOM,
  title={Effect of maraviroc on the pharmacokinetics of midazolam, lamivudine/zidovudine, and ethinyloestradiol/levonorgestrel in healthy volunteers.},
  author={Samantha Abel and Deborah Russell and Lyndsey A Whitlock and Caroline E Ridgway and G. Muirhead},
  journal={British journal of clinical pharmacology},
  year={2008},
  volume={65 Suppl 1},
  pages={19-26}
}
AIMS To assess the effect of maraviroc on the pharmacokinetics of midazolam, a sensitive probe CYP3A4 substrate; lamivudine/zidovudine, a combination of nucleoside reverse transcriptase inhibitors (NRTIs); and ethinyloestradiol/levonorgestrel, a combination oral contraceptive. METHODS Three randomized, double-blind, placebo-controlled studies were conducted in healthy subjects to assess the effect of maraviroc on pharmacokinetics of other drugs. Two, two-period crossover studies were… CONTINUE READING

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