Effect of manganese on tyrosylprotein sulfotransferase activity in PC12 cells.


Recent studies in our laboratory have revealed that Mn2+ is capable of promoting cell spreading and neurite outgrowth in PC12 cells, a process which is dependent on Mn2+ stimulation of the interaction between extracellular matrix (ECM) components and their corresponding integrin receptors. Since the major ECM proteins implicated in the Mn(2+)-induced… (More)


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