Effect of manganese and copper interaction on behavior and biogenic amines in rats fed a 10% casein diet.

  title={Effect of manganese and copper interaction on behavior and biogenic amines in rats fed a 10\% casein diet.},
  author={Ramesh Chandra Murthy and S Lal and Daya Krishna Saxena and Girja S. Shukla and M. M. Ali and Satya V. Chandra},
  journal={Chemico-biological interactions},
  volume={37 3},

The effect of manganese-induced hypercholesterolemia on learning in rats

Results suggested that Mn-induced hypercholesterolemia is involved in Mn-dependent learning disability, and the correction of impaired learning was associated with the normalization of hippocampal cholesterol.

Effect of daily oral intake of manganese on free polysomal protein synthesis of rat brain.

The data suggest that the previously reported retardation in learning and memory of manganese treated immature rats may partly be due to alteration of cerebral RNA and protein synthesis.

Monoamine uptake in brain synaptosomes after administration of copper to rats.

  • H. Komulainen
  • Biology, Chemistry
    Acta pharmacologica et toxicologica
  • 1983
The results indicate that Cu is not liable to affect monoamine uptake in nerve endings in vivo, which may be explained by effective endogenous protective mechanisms against Cu.

Supersensitivity of the cholinergic muscarinic system in the rat's brain is induced by high concentrations of Cu+2.

45 days of Cu2+ or PA treatment induced brain hypercuprosis, which was associated with MR binding supersensitivity; however, change in ME was only observed in PA treated rats suggesting that might be still another factor in these experiments besides Cu2- (i.e., Zn2- or PA itself) involved in memory modulation.

Effect of cadmium exposure on lipids, lipid peroxidation and metal distribution in rat brain regions.

Results suggest that the increased peroxidation decomposition of structural lipids and the altered distribution of the essential trace metals in brain may play a significant role in Cd-induced neurotoxicity.



Combined effect of metals on biogenic amines and their distribution in the brain of mice

Combined exposure to manganese and copper resulted in marked accumulation of copper in the brain, of great concern, since excess copper in brain produces incoordination in body movements.

Effect of manganese on synthesis of brain catecholamines in growing rats.

The effect of short-term exposure of manganese on the synthesis of brain catecholamines in growing rats has been investigated by measuring the amount of conversion and the rate of decline of endogenous dopamine and norepinephrine following inhibition of their synthesis with alpha-methyl-p-tyrosine.


An animal model of early manganese poisoning has been developed with a possible role of striatal amines in the production of behavioral dysfunction in the treated mice.


The conditioned response was utilized to examine the interactions of lysergic acid diethylamide with reserpine and serotonin, as well as chlorpromazine, morphine, and meprobamate for possible interaction with conditioned-response blocking agents.

Pharmacological significance of biogenic amines in the lungs: 5‐hydroxytryptamine

A technique for the spectrofluorometric analysis of 5‐hydroxytryptamine, histamine, noradrenaline and dopamine in a single lung sample has been developed and it has been possible to analyse all four amines from a sample of the lung in which the bronchopulmonary responses have been investigated.

Central nervous system effects of thalidomide.

Thalidomide potentiates the effect of anticonvulsants on maximal electroshock seizures but does not alter the acute toxicity of these drugs.

5-Hydroxytryptamine and Other Indoles in the Central Nervous System

Although this review concentrates on the biochemistry and pharmacology of 5-hydroxytryptamine (5-HT) and related indolealkylamines in the central nervous system, any physiological role which these

Determination of Na+, K+, Mg2+, Cu2+, Zn2+, and Mn2+ in Rat Brain Regions

Na+, K+, Mg2+, Cu2+, Zn2+, and Mn2+ were determined in several regions of rat brain, using atomic absorption spectroscopy. Cu2+ was highest in the hypothalamus and lowest in the medulla oblongata.