Effect of malate and NAD on local myocardial contractility during acute coronary arterial occlusion

Abstract

When the protective action of drugs on the ischemic myocardium is assessed, very often recovery of electrophysiological, biochemical, and histologic parameters are regarded as equivalent to manifestation of viability of the myocardium. However, as Hearse [5] has rightly pointed out, we can hardly speak of the protective action of drugs unless the contractile function of the "rescued" myocardium recovers. The present writer showed previously that malate and NAD increase contractility and the pumping function of the acutely ischemic heart. However, it is not yet clear whether these substances can restore myocardial contractile function in an ischemic focus, for the effects observed may have been due to their action on intact zones of the affected heart.

DOI: 10.1007/BF00842238

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Cite this paper

@article{Kostin2004EffectOM, title={Effect of malate and NAD on local myocardial contractility during acute coronary arterial occlusion}, author={Victor I. Kostin}, journal={Bulletin of Experimental Biology and Medicine}, year={2004}, volume={102}, pages={1217-1219} }