Effect of magnesium supplementation on glucose metabolism in people with or at risk of diabetes: a systematic review and meta-analysis of double-blind randomized controlled trials

@article{Veronese2016EffectOM,
  title={Effect of magnesium supplementation on glucose metabolism in people with or at risk of diabetes: a systematic review and meta-analysis of double-blind randomized controlled trials},
  author={N. Veronese and S. Watutantrige-Fernando and C. Luchini and M. Solmi and G. Sartore and G. Sergi and E. Manzato and M. Barbagallo and S. Maggi and B. Stubbs},
  journal={European Journal of Clinical Nutrition},
  year={2016},
  volume={70},
  pages={1354-1359}
}
Although higher dietary intakes of magnesium (Mg) seem to correspond to lower diabetes incidence, research concerning Mg supplementation in people with or at risk of diabetes is limited. Thus, we aimed to investigate the effect of oral Mg supplementation on glucose and insulin-sensitivity parameters in participants with diabetes or at high risk of diabetes compared with placebo. A literature search in PubMed, EMBASE, SCOPUS, Cochrane Central Register of Controlled Trials and Clinicaltrials.gov… Expand
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TLDR
It is concluded that magnesium supplementation does not improve metabolic control or insulin sensitivity in diabetic subjects with normomagnesemia. Expand
Oral magnesium supplementation reduces insulin resistance in non‐diabetic subjects – a double‐blind, placebo‐controlled, randomized trial
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There is significant evidence that oral Mg supplementation improves insulin sensitivity even in normomagnesemic, overweight, non‐diabetic subjects emphasizing the need for an early optimization of Mg status to prevent insulin resistance and subsequently type 2 diabetes. Expand
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Mg depletion is common in poorly controlled patients with type 2 diabetes, especially in those with neuropathy or coronary disease, and more prolonged use of Mg in doses that are higher than usual is needed to improve control or prevent chronic complications. Expand
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The results show that magnesium supplementation reduces plasma glucose levels, and improves the glycaemic status of adults with prediabetes and hypomagnesaemia. Expand
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TLDR
Oral supplementation with MgCl(2) solution restores serum magnesium levels, improving insulin sensitivity and metabolic control in type 2 diabetic patients with decreased serum magnesium Levels. Expand
Magnesium Replacement Does Not Improve Insulin Resistance in Patients With Metabolic Syndrome: A 12-Week Randomized Double-Blind Study
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Serum and intracellular Mg depletion is common in patients with MS; however, Mg replacement in recommended dosage did not increase significantly Mg levels, neither reduced insulin resistance or metabolic control. Expand
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TLDR
Magnesium supplementation among women with GDM had beneficial effects on metabolic status and pregnancy outcomes and the change in serum magnesium concentration was greater in women consuming magnesium than in the placebo group. Expand
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TLDR
Oral magnesium supplementation in the doses and duration studied is modestly effective in reducing systolic blood pressure in patients with NIDDM but has little impact on other important biochemical parameters related to diabetes-associated end-organ disease. Expand
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TLDR
This meta-analysis provides further evidence supporting that magnesium intake is significantly inversely associated with risk of type 2 diabetes in a dose-response manner. Expand
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TLDR
Magnesium supplementation for 4 wk in overweight individuals led to distinct changes in gene expression and proteomic profiling consistent with favorable effects on several metabolic pathways. Expand
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