Effect of macromolecular crowding on reaction rates: a computational and theoretical study.

@article{Kim2009EffectOM,
  title={Effect of macromolecular crowding on reaction rates: a computational and theoretical study.},
  author={Jun Soo Kim and Arun Yethiraj},
  journal={Biophysical journal},
  year={2009},
  volume={96 4},
  pages={1333-40}
}
The effect of macromolecular crowding on the rates of association reactions are investigated using theory and computer simulations. Reactants and crowding agents are both hard spheres, and when two reactants collide they form product with a reaction probability, p(rxn). A value of p(rxn) < 1 crudely mimics the fact that proteins must be oriented properly for an association reaction to occur. The simulations show that the dependence of the reaction rate on the volume fraction of crowding agents… CONTINUE READING

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