Effect of lysophosphatidylcholine on renal hemodynamics and excretory function in anesthetized rats.

Abstract

The effect of myristoyl-lysophosphatidylcholine (myristoyl-LPC) on renal hemodynamics, electrolyte and water excretion was examined over a 90 min period in sodium pentobarbital anesthetized male Sprague Dawley rats. Intravenous infusion of myristoyl-LPC at 13 +/- 3 pmol/min resulted in a small fall in systemic blood pressure, a 13% decrease in renal plasma flow without significantly altering glomerular filtration rate and produced a slightly greater excretion of sodium and water than vehicle controls. These results suggest that short term myristoyl-LPC administration can significantly alter renal function producing a weak natriuresis and diuresis which is not dependent on systemic blood pressure and renal hemodynamic changes.

Cite this paper

@article{Handa1992EffectOL, title={Effect of lysophosphatidylcholine on renal hemodynamics and excretory function in anesthetized rats.}, author={Rajash K Handa and Vardaman M. Buckalew}, journal={Life sciences}, year={1992}, volume={51 20}, pages={1571-5} }