Effect of lymphocytic infiltration on the blood-retinal barrier in experimental autoimmune uveoretinitis.

@article{Lightman1992EffectOL,
  title={Effect of lymphocytic infiltration on the blood-retinal barrier in experimental autoimmune uveoretinitis.},
  author={Susan L. Lightman and John Greenwood},
  journal={Clinical and experimental immunology},
  year={1992},
  volume={88 3},
  pages={473-7}
}
Using an experimental model of autoimmune uveoretinitis, we have examined the relationship of T cell infiltration in the retina to blood-retinal barrier (BRB) breakdown. Sensitive quantitative in vivo techniques were used to examine BRB permeability to sucrose, a low mol. wt non-transported solute. Electron microscopy was also used to localize extravasated horseradish peroxidase, a macromolecular visual tracer, from the retinal vasculature and to identify the route by which any leakage was… CONTINUE READING

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