Effect of luminal sodium concentration on bicarbonate absorption in rat jejunum.

  title={Effect of luminal sodium concentration on bicarbonate absorption in rat jejunum.},
  author={Kenneth A. Hubel},
  journal={The Journal of clinical investigation},
  volume={52 12},
An exchange of Na(+) for H(+) has been proposed to explain why jejunal Na(+) absorption is influenced by luminal concentrations of H(+) and HCO(3) (-). We studied the influence of luminal Na(+) concentration on net HCO(3) (-) absorption by perfusing rat jejunum in vivo. When Na(+) was omitted from the perfusion fluid, HCO(3) (-) absorption diminished by a fixed amount over a range of initial HCO(3) (-) concentrations of 15 to 80 mM. This change was not caused by alterations in transmural PD or… CONTINUE READING


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