Effect of luminal growth factor preservation on intestinal growth

@article{Playford1993EffectOL,
  title={Effect of luminal growth factor preservation on intestinal growth},
  author={Raymond John Playford and Anthony C. Woodman and David A Vesey and Pierre H Deprez and John Calam and Prasit Watanapa and Robin C. N. Williamson and Patsy Clark},
  journal={The Lancet},
  year={1993},
  volume={341},
  pages={843-848}
}
Intestinal atrophy contributes to the clinical difficulties of patients who cannot eat normally. Atrophy is prevented by luminal food proteins but not by the equivalent aminoacids. This observation is not explained by current theories of intestinal physiology. Epidermal growth factor (EGF) and transforming growth factor alpha (TGF alpha) are secreted into the gut lumen. We speculated that these are digested by pancreatic enzymes in fasting juice, but preserved when food proteins block the… Expand
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