Effect of loxapine on electrical brain activity, intracranial pressure, and middle cerebral artery flow velocity in traumatic brain-injured patients.

@article{Lescot2007EffectOL,
  title={Effect of loxapine on electrical brain activity, intracranial pressure, and middle cerebral artery flow velocity in traumatic brain-injured patients.},
  author={Thomas Lescot and Ana Paula da Rosa Pereira and Lamine Abdennour and Paola Sanchez-Pe{\~n}a and Lionel Naccache and Pierre Coriat and Louis Puybasset},
  journal={Neurocritical care},
  year={2007},
  volume={7 2},
  pages={124-7}
}
INTRODUCTION Delirium is a frequent complication of traumatic brain injury, especially during the weaning period. Antipsychotic drugs are often used in this case. Loxapine is a tricyclic antipsychotic drug with sedating properties. The effects of intravenous loxapine on EEG as well as on systemic and cerebral hemodynamics after traumatic brain injury are unknown. METHODS Seven sedated and mechanically ventilated traumatic brain injured patients were studied 11 +/- 5 days after trauma. They… CONTINUE READING

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