Effect of lower doses of conjugated equine estrogens with and without medroxyprogesterone acetate on bone in early postmenopausal women.

@article{Lindsay2002EffectOL,
  title={Effect of lower doses of conjugated equine estrogens with and without medroxyprogesterone acetate on bone in early postmenopausal women.},
  author={Robert F. Lindsay and John Christopher Gallagher and Michael Kleerekoper and James H. Pickar},
  journal={JAMA},
  year={2002},
  volume={287 20},
  pages={2668-76}
}
CONTEXT Lower-than-commonly-prescribed doses of conjugated equine estrogens (CEEs) with medroxyprogesterone acetate (MPA) improve vasomotor symptoms and vaginal atrophy, provide acceptable bleeding and lipid profiles, and afford endometrial protection. This lower-dose therapy's protection against loss of bone mineral density (BMD) associated with menopause has not been thoroughly investigated. OBJECTIVE To determine the effects of lower doses of CEEs only or CEEs-MPA on spine and hip BMD… CONTINUE READING
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