Effect of low-dose tacrolimus coadministered with raloxifene on the skeletal system in male rats.


Tacrolimus is an immunosuppressive drug, used to prevent organ transplant rejection. Immunosuppresants are known to unfavorably affect the osseous system. However, in our previous study on bone histomorphometric parameters we observed that low-dose tacrolimus intensified bone formation. The aim of the present study was to investigate the effects of low-dose… (More)


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