Effect of low-dose ketamine on post-operative serum IL-6 production among elective surgical patients: a randomized clinical trial.

@article{Luggya2017EffectOL,
  title={Effect of low-dose ketamine on post-operative serum IL-6 production among elective surgical patients: a randomized clinical trial.},
  author={Tonny Stone Luggya and Tony Roche and Lameck Ssemogerere and Andrew Kintu and John Mark Kasumba and Arthur Kwizera and Jose Vb Tindimwebwa},
  journal={African health sciences},
  year={2017},
  volume={17 2},
  pages={500-507}
}
BACKGROUND Surgery and Anesthesia cause an excessive pro-inflammatory response. Mulago Hospital is faced with staff shortage making post-operative pain management difficult.Interleukin-6 (IL-6) drives inflammatory pain, endothelial cell dysfunction and fibrogenesis. Ketamine is cheap and, readily available. We hypothesized that its attenuation of serum IL-6 was a surrogate for clinical benefit. MATERIALS AND METHODS Institutional Review Board's approval was sought and RCT was registered at… CONTINUE READING