Effect of low-dose exogenous secretin and somatostatin on pentagastrin-stimulated gastric acid secretion in man.

@article{Olsen1989EffectOL,
  title={Effect of low-dose exogenous secretin and somatostatin on pentagastrin-stimulated gastric acid secretion in man.},
  author={J. Olsen and P. Mortensen and O. B. Schaffalitzky de Muckadell and J. Holst and John R. Christiansen},
  journal={Scandinavian journal of gastroenterology},
  year={1989},
  volume={24 4},
  pages={
          493-6
        }
}
The inhibitory effect of intravenous infusion of secretin (0.05 CU kg-1h-1) and somatostatin (60 pmol kg-1h-1), given alone or in combination, on pentagastrin-stimulated (100 ng kg-1 h-1) acid secretion was studied in 10 healthy subjects. Secretin inhibited acid secretion by 54% (p less than 0.05), and somatostatin inhibited by 70% (p less than 0.05). The combined infusion of secretin and somatostatin decreased acid output by 64% (p less than 0.05). The differences between the three groups were… Expand

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