Effect of low- and high-frequency TENS on Met-enkephalin-Arg-Phe and dynorphin A immunoreactivity in human lumbar CSF.

@article{Han1991EffectOL,
  title={Effect of low- and high-frequency TENS on Met-enkephalin-Arg-Phe and dynorphin A immunoreactivity in human lumbar CSF.},
  author={Ji-sheng Han and Xiao Hong Chen and Shao Liang Sun and X. J. Xu and Y Yuan and Shan Chun Yan and J. X. Hao and Lars Terenius},
  journal={Pain},
  year={1991},
  volume={47 3},
  pages={295-8}
}
Transcutaneous nerve stimulation (TENS) treatment was given for 30 min to 37 patients divided into 3 groups of 10 patients and 1 group of 7 patients. Two groups received low-frequency (2 Hz) and the other 2 groups high-frequency (100 Hz) stimulation. A diagnostic lumbar cerebrospinal fluid (CSF) sample was obtained immediately before and after stimulation. The CSF samples were subjected to analysis of immunoreactive (ir) opioid peptides, Met-enkephalin-Arg-Phe (MEAP) from preproenkephalin and… CONTINUE READING