Effect of losartan pretreatment on kidney lipid content after unilateral obstruction in rats.

@article{Manucha2005EffectOL,
  title={Effect of losartan pretreatment on kidney lipid content after unilateral obstruction in rats.},
  author={Walter A. F. Manucha and Liliana Carmen Carrizo and Sergio {\'A}lvarez and Patricia Vall{\'e}s and Liliana Beatriz Oliveros},
  journal={Cellular and molecular biology},
  year={2005},
  volume={51 6},
  pages={539-45}
}
Intrarenal concentration of angiotensin II increases after the onset of ureteral obstruction in the obstructed kidney. The effect of pretreatment with losartan, a specific angiotensin II AT1 receptor antagonist, on lipid contents, which were previously modified by unilateral ureteral obstruction (UUO), was studied in renal cortex of rats. Adult Wistar Kyoto rats were subjected to either UUO for 24 hr or control sham operation after being treated with losartan in the drinking water at 10 mg/kg… CONTINUE READING