Effect of long-term valproate monotherapy on bone mineral density in adults with epilepsy.

@article{Triantafyllou2010EffectOL,
  title={Effect of long-term valproate monotherapy on bone mineral density in adults with epilepsy.},
  author={Nikos I Triantafyllou and Irini Lambrinoudaki and Elena Armeni and E Evangelopoulos and Fotini Boufidou and Aris Antoniou and G Tsivgoulis},
  journal={Journal of the neurological sciences},
  year={2010},
  volume={290 1-2},
  pages={131-4}
}
BACKGROUND We evaluated the cross-sectional relationship of duration and dosage of valproate monotherapy on bone mineral density (BMD) in adult patients with epilepsy. METHODS The BMD at lumbar level (L2-L4) was measured in consecutive adult epileptic patients receiving long-term (> or =2 years) valproate monotherapy by dual energy X-ray absorptiometry (DXA). Blood samples were collected for total serum calcium, phosphorus, magnesium, 25-hydroxyvitamin D(3) and parathormone. Osteopenia and… CONTINUE READING

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