Effect of long term treatment with calcitriol on calcium absorption and mineral metabolism in postmenopausal osteoporosis.

@article{Riggs1985EffectOL,
  title={Effect of long term treatment with calcitriol on calcium absorption and mineral metabolism in postmenopausal osteoporosis.},
  author={B. Lawrence Riggs and Kristin I Nelson},
  journal={The Journal of clinical endocrinology and metabolism},
  year={1985},
  volume={61 3},
  pages={457-61}
}
The mechanism of impaired calcium absorption in postmenopausal osteoporosis is controversial. If it is caused by calcitriol deficiency, it should be corrected by long term administration of physiological doses of this metabolite, whereas if it is caused by either a primary defect in calcium absorption or intestinal resistance to calcitriol action, it should not be. In 56 osteoporotic women, mean (+/- SE) fractional calcium absorption (0.52 +/- 0.02) was lower (P less than 0.001) than that in 20… CONTINUE READING