Effect of long-term treatment with aromatase inhibitor on testicular function of adult male bonnet monkeys (M. radiata)

@article{Shetty1998EffectOL,
  title={Effect of long-term treatment with aromatase inhibitor on testicular function of adult male bonnet monkeys (M. radiata)},
  author={Gunapala Shetty and Hanumanthappa Krishnamurthy and H. Krishnamurthy and Ajay S. Bhatnagar and N. R. Moudgal},
  journal={Steroids},
  year={1998},
  volume={63},
  pages={414-420}
}
The role/need for estrogen in regulating testicular function of adult male bonnet monkeys (M. radiata) has been investigated by dosing orally a group of five normal males 2.5 mgs of CGP 47645, a long-acting nonsteroidal aromatase inhibitor (AI), once every 5 days for over 150 days. Such treatment resulted in a 10-fold increment in nocturnal serum testosterone (T) levels, which were sustained for 85 days of treatment, and a twofold increment in basal serum T levels was present throughout the 150… Expand
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