Effect of long-term treatment with an anticholinergic drug on gastric secretion in rats

@article{Kowalewski1967EffectOL,
  title={Effect of long-term treatment with an anticholinergic drug on gastric secretion in rats},
  author={M. D. K. Kowalewski},
  journal={The American Journal of Digestive Diseases},
  year={1967},
  volume={12},
  pages={988-993}
}
An anticholinergic, propantheline bromide, was given in a dosage of 5 mg./ kg. body weight twice daily to rats. Gastric function was studied after 3, 6, 9, and 12 months of this treatment. Gastric content was collected after (1) pyloric and cardia ligation; (2) pyloric ligation only; and (3) during a 24-hr, intravenous infusion of histamine. Under the… CONTINUE READING