Effect of long-term therapy with ramipril in high-risk women.

  title={Effect of long-term therapy with ramipril in high-risk women.},
  author={Eva M. Lonn and Rosa Roccaforte and Qilong Yi and Gilles R. Dagenais and Peter J. Sleight and Jackie Bosch and Pamela Suhan and Mary Micks and Jeffrey Lynn Probstfield and Victoria Bernstein and Salim Yusuf},
  journal={Journal of the American College of Cardiology},
  volume={40 4},
OBJECTIVES We evaluated the effects of long-term therapy with the angiotensin-converting enzyme (ACE) inhibitor ramipril on major cardiovascular (CV) outcomes in high-risk women. BACKGROUND The effect of long-term ACE inhibitor therapy in high-risk women without heart failure and with preserved left ventricular (LV) systolic function has not been previously reported. METHODS The Heart Outcomes Prevention Evaluation (HOPE) trial is a large, randomized clinical trial that evaluated ramipril… CONTINUE READING


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