Effect of long-term inhibition of hydroxy-methylglutaryl coenzyme A reductase by mevinolin on the zona fasciculata of rat adrenal cortex. A combined morphometric and biochemical study.

Abstract

The effects of a 7-day infusion with mevinolin, a potent competitive inhibitor of hydroxy-methylglutaryl coenzyme A (HMG-CoA) reductase, on the adrenal zona fasciculata were examined in normal and dexamethasone/ACTH-treated rats. In both groups of animals, the drug caused a lowering in plasma and intra-adrenal cholesterol concentrations, as well as a slight… (More)

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@article{Rebuffat1987EffectOL, title={Effect of long-term inhibition of hydroxy-methylglutaryl coenzyme A reductase by mevinolin on the zona fasciculata of rat adrenal cortex. A combined morphometric and biochemical study.}, author={Piera Rebuffat and Giuseppina Mazzocchi and Gastone Giovanni Nussdorfer}, journal={Virchows Archiv. B, Cell pathology including molecular pathology}, year={1987}, volume={54 2}, pages={67-72} }