Effect of long-term immunosuppression in kidney-graft recipients on cancer incidence: randomised comparison of two cyclosporin regimens

@article{Dantal1998EffectOL,
  title={Effect of long-term immunosuppression in kidney-graft recipients on cancer incidence: randomised comparison of two cyclosporin regimens},
  author={J. Dantal and M. Hourmant and D. Cantarovich and M. Giral and J. Soulillou},
  journal={The Lancet},
  year={1998},
  volume={351},
  pages={623-628}
}
BACKGROUND Long-term administration of cyclosporin carries a risk of renal toxicity, and immunosuppressants are associated with an increased rate of malignant disorders. We undertook an open randomised study of the risks and benefits of two long-term maintenance regimens of cyclosporin in kidney-allograft recipients. The primary endpoint was graft function; secondary endpoints were survival and occurrence of cancer and rejection. METHODS 231 recipients of a first allograft with at most one… Expand
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