Effect of long-term and high-dose allopurinol therapy on endothelial function in normotensive diabetic patients.

  title={Effect of long-term and high-dose allopurinol therapy on endothelial function in normotensive diabetic patients.},
  author={Ali Dogan and Mikail Yarlioğlueş and Mehmet Gux0308ngox0308r Kaya and Zakir Karadağ and Serap Melek Doğan and Idris Ardiç and Orhan Doğdu and Yusuf Kilinc and Cemil Zencir and Mahmut Akpek and Ibrahim Ozdoğru and Abdurrahman Oğuzhan and Nihat Kalay},
  journal={Blood pressure},
  volume={20 3},
OBJECTIVES Endothelial dysfunction is a well known risk factor for atherosclerosis. Uric acid levels are associated with endothelial dysfunction and atherosclerosis even if in physiological range. Xanthine oxidase inhibition with allopurinol decreases uric acid levels and oxidative stress and improves endothelial function. We have investigated the effect of high-dose and long-term allopurinol therapy on endothelial function in diabetic normotensive patients. METHODS This study is a randomized… CONTINUE READING


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