Effect of long-acting nifedipine on mortality and cardiovascular morbidity in patients with stable angina requiring treatment (ACTION trial): randomised controlled trial

@article{Poolewilson2004EffectOL,
  title={Effect of long-acting nifedipine on mortality and cardiovascular morbidity in patients with stable angina requiring treatment (ACTION trial): randomised controlled trial},
  author={P. Poole-wilson and J. Lubsen and Bridget‐Anne Kirwan and F. J. Dalen and on behalf of the Action investigators},
  journal={The Lancet},
  year={2004},
  volume={364},
  pages={849-857}
}
  • P. Poole-wilson, J. Lubsen, +2 authors on behalf of the Action investigators
  • Published 2004
  • Medicine
  • The Lancet
  • BACKGROUND Calcium antagonists are widely prescribed for angina pectoris but their effect on clinical outcome is controversial. We aimed to investigate the effect of the calcium antagonist nifedipine on long-term outcome in patients with stable angina pectoris. METHODS We randomly assigned 3825 patients with treated stable symptomatic coronary disease to double-blind addition of nifedipine GITS (gastrointestinal therapeutic system) 60 mg once daily and 3840 to placebo. The primary endpoint… CONTINUE READING
    474 Citations
    Long-term impact of secondary preventive treatments in patients with stable angina
    • 5
    • PDF
    The ACTION study: nifedipine in patients with symptomatic stable angina and hypertension
    • 17

    References

    SHOWING 1-10 OF 34 REFERENCES