• DOI:10.1016/S0140-6736(04)16980-8
Corpus ID: 12795811

Effect of long-acting nifedipine on mortality and cardiovascular morbidity in patients with stable angina requiring treatment (ACTION trial): randomised controlled trial

@article{Poolewilson2004EffectOL,
  title={Effect of long-acting nifedipine on mortality and cardiovascular morbidity in patients with stable angina requiring treatment (ACTION trial): randomised controlled trial},
  author={P. Poole-wilson and J. Lubsen and Bridget‐Anne Kirwan and F. J. Dalen and on behalf of the Action investigators},
  journal={The Lancet},
  year={2004},
  volume={364},
  pages={849-857}
}

P. Poole-wilson, J. Lubsen, +2 authors on behalf of the Action investigators

Published 2004

Medicine

The Lancet

BACKGROUND Calcium antagonists are widely prescribed for angina pectoris but their effect on clinical outcome is controversial. We aimed to investigate the effect of the calcium antagonist nifedipine on long-term outcome in patients with stable angina pectoris. METHODS We randomly assigned 3825 patients with treated stable symptomatic coronary disease to double-blind addition of nifedipine GITS (gastrointestinal therapeutic system) 60 mg once daily and 3840 to placebo. The primary endpoint… CONTINUE READING

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