Effect of long-acting nifedipine on mortality and cardiovascular morbidity in patients with stable angina requiring treatment (ACTION trial): randomised controlled trial
@article{Poolewilson2004EffectOL, title={Effect of long-acting nifedipine on mortality and cardiovascular morbidity in patients with stable angina requiring treatment (ACTION trial): randomised controlled trial}, author={P. Poole-wilson and J. Lubsen and Bridget‐Anne Kirwan and F. J. Dalen and on behalf of the Action investigators}, journal={The Lancet}, year={2004}, volume={364}, pages={849-857} }
BACKGROUND
Calcium antagonists are widely prescribed for angina pectoris but their effect on clinical outcome is controversial. We aimed to investigate the effect of the calcium antagonist nifedipine on long-term outcome in patients with stable angina pectoris.
METHODS
We randomly assigned 3825 patients with treated stable symptomatic coronary disease to double-blind addition of nifedipine GITS (gastrointestinal therapeutic system) 60 mg once daily and 3840 to placebo. The primary endpoint… CONTINUE READING
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References
SHOWING 1-10 OF 34 REFERENCES
Design and current status of ACTION: A Coronary disease Trial Investigating Outcome with Nifedipine GITS. Gastro-Intestinal Therapeutic System.
- Medicine
- European heart journal
- 1998
- 47
Morbidity and mortality in patients randomised to double-blind treatment with a long-acting calcium-channel blocker or diuretic in the International Nifedipine GITS study: Intervention as a Goal in Hypertension Treatment (INSIGHT)
- Medicine
- The Lancet
- 2000
- 1,164
Efficacy of perindopril in reduction of cardiovascular events among patients with stable coronary artery disease: randomised, double-blind, placebo-controlled, multicentre trial (the EUROPA study).
- Medicine
- Lancet
- 2003
- 1,855
- PDF
Total Ischaemic Burden European Trial (TIBET). Effects of ischaemia and treatment with atenolol, nifedipine SR and their combination on outcome in patients with chronic stable angina. The TIBET Study Group.
- Medicine
- European heart journal
- 1996
- 220
- PDF
Long term effects of nisoldipine on the progression of coronary atherosclerosis and the occurrence of clinical events: the NICOLE study
- Medicine
- Heart
- 2003
- 47
- PDF
Randomised trial of old and new antihypertensive drugs in elderly patients: cardiovascular mortality and morbidity the Swedish Trial in Old Patients with Hypertension-2 study
- Medicine
- The Lancet
- 1999
- 1,426
- PDF
Randomised trial of effects of calcium antagonists compared with diuretics and β-blockers on cardiovascular morbidity and mortality in hypertension: the Nordic Diltiazem (NORDIL) study
- Medicine
- The Lancet
- 2000
- 922
- PDF
Nifedipine. Dose-related increase in mortality in patients with coronary heart disease.
- Medicine
- Circulation
- 1995
- 1,142