Effect of locally delivered IGF-1 on nerve regeneration during aging: an experimental study in rats.

@article{Apel2010EffectOL,
  title={Effect of locally delivered IGF-1 on nerve regeneration during aging: an experimental study in rats.},
  author={Peter James Apel and Jianjun Ma and Michael Callahan and Casey N Northam and T. Alton and William Edmund Sonntag and Zhongyu Li},
  journal={Muscle & nerve},
  year={2010},
  volume={41 3},
  pages={335-41}
}
Age is an important predictor of neuromuscular recovery after peripheral nerve injury. Insulin-like growth factor 1 (IGF-1) is a potent neurotrophic factor that is known to decline with increasing age. The purpose of this study was to determine if locally delivered IGF-1 would improve nerve regeneration and neuromuscular recovery in aged animals. Young and aged rats underwent nerve transection and repair with either saline or IGF-1 continuously delivered to the site of the nerve repair. After 3… CONTINUE READING

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