Effect of locally applied prazosin on the kinetics of the pupillary light reflex.

@article{Mortlock1996EffectOL,
  title={Effect of locally applied prazosin on the kinetics of the pupillary light reflex.},
  author={S A Mortlock and Robert William Langley and Christopher M. Bradshaw and Elem{\'e}r Szabadi},
  journal={British journal of clinical pharmacology},
  year={1996},
  volume={42 2},
  pages={
          236-8
        }
}
The effect of locally applied prazosin on pupillometric measures was studied in healthy volunteers, in an attempt to identify the role of alpha 1-adrenoceptors in the recovery time of the light reflex. Prazosin antagonized the mydriatic effect of phenylephrine, but did not alter that of tropicamide. Miotic responses to a range of light stimuli were measured under ambient temperature conditions of 22 degrees C and 40 degrees C. The 40 degrees C condition was associated with shorter recovery… CONTINUE READING
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