Effect of local zoledronate on implant osseointegration in a rat model

@inproceedings{Back2012EffectOL,
  title={Effect of local zoledronate on implant osseointegration in a rat model},
  author={David Alexander Back and Stephan Pauly and Lisa Rommel and N. P. Haas and Gerhard Schmidmaier and Britt Wildemann and Stefan H. Greiner},
  booktitle={BMC musculoskeletal disorders},
  year={2012}
}
BACKGROUND An implant coating with poly(D, L-lactide) (PDLLA) releasing incorporated zoledronic acid (ZOL) has already proven to positively effect osteoblasts, to inhibit osteoclasts and to accelerate fracture healing. Aim of this study was to investigate the release kinetics of the chosen coating and the effect of different concentrations of ZOL locally released from this coating on the osseointegration of implants. METHODS For release kinetics the release of C14-labled ZOL out of the… CONTINUE READING