Effect of local GABA administration on rat ovarian blood flow, and on progesterone and estradiol secretion.

  title={Effect of local GABA administration on rat ovarian blood flow, and on progesterone and estradiol secretion.},
  author={S{\'a}ndor L. Erdő and Bertalan Varga and Edit Horvath},
  journal={European journal of pharmacology},
  volume={111 3},
Pregnancy in rats is modulated by ganglionic cholinergic action.
It is concluded that the cholinergic sympathetic system from the celiac ganglion might be a fine modulator of the pregnancy physiology.
Ganglionic adrenergic action modulates ovarian steroids and nitric oxide in prepubertal rat.
It is concluded that the ganglionic adrenergic action via SON participates on the regulation of the prepubertal ovary in one of two ways: either increasing the NO, a gaseous neurotransmitter with cytostatic characteristics, to favour the immature follicles to remain dormant or increasing the liberation of androstenedione and oestradiol, the steroids necessary for the beginning of the near first estral cycle.
Excitatory and inhibitory influence of exogenous neurotransmitters on reproduction in female rats
The role of the excitatory-glutamate and inhibitory-GABA transmitters in female rats reproduction including their effects on gonadotropins; luteinizing hormone (LH) and follicle stimulating hormone (FSH) and the sex steroids; estrogen (E2) and progesterone (P4) during the estrous cycle was investigated.
Superior mesenteric ganglion neural modulation of ovarian angiogenesis, apoptosis and proliferation by the neuroactive steroid allopregnanolone
Allopregnanolone participates in the peripheral neural modulation of ovarian physiology, modulating key mechanisms involved in normal and pathological processes in a dose‐dependent manner.
The role of the muscarinic system in regulating estradiol secretion varies during the estrous cycle: the hemiovariectomized rat model
The results indicate that ULO effects on E2 concentrations are asymmetric, vary during the estrous cycle, and partially depend on the cholinergic innervation, and support the idea of cross-talk between the ovaries, via a neural communication, that modulates E2 secretion.
Coeliac ganglion adrenergic activity modifies ovarian progesterone during pregnancy: its inter-relationship with LH.
Modifications of the neural state of the coeliac ganglion affect ovarian progesterone secretion and the physiology of pregnancy via the SON, and the results may confirm that the Coeliac Ganglion-SON-ovary system provides a direct link between the autonomic nervous system and physiological events during pregnancy.
Adrenergic influences on coeliac ganglion affect the release of progesterone from cycling ovaries: characterisation of an in vitro system.
The in vitro coeliac ganglion-SON-ovary system is a functional entity because it possesses its own autonomic tone and variations of progesterone induced via the neural pathway were observed under different experimental conditions.
Relaxatory Effect of Gamma-Aminobutyric Acid (GABA) is Mediated by Same Pathway in Diabetic and Normal Rat Mesenteric Bed vessel
The vasorelaxatory effect of Gamma aminobutyric acid (GABA) on diabetic vessels and the role of endothelium in GABAinduced vasoreLaxation were determined.
Acute effects of unilateral sectioning the superior ovarian nerve of rats with unilateral ovariectomy on ovarian hormones (progesterone, testosterone and estradiol) levels vary during the estrous cycle
Results support the idea that the ovaries send and receive neural information that is processed in the central nervous system and propose that this information participates in controlling the secretion of gonadotropins related to the regulation of ovarian functions.


Increase of ovarian progesterone secretion by beta 2-adrenergic stimulation in oestrous rats.
It is suggested that ovarian beta 2-adrenergic receptors have a regulatory role in ovarian hormone secretion and fenoterol administered iv increased P secretion without altering ovarian blood flow, whereas noradrenaline and isoproterenol had no effect on P secretion.
High‐Affinity, Sodium‐Dependent Γ‐Aminobutyric Acid Uptake by Slices of Rat Ovary
The results suggest that the uptake system in ovary possesses properties similar to those of high-affinity GABA transport systems in the brain.
gamma-Aminobutyric acid and postganglionic sympathetic transmission in the pulmonary artery of the rabbit.
The results show that, in the pulmonary artery of the rabbit, GABA inhibits the release of noradrenaline and its effect is independent of alpha- and beta-adrenoreceptors and is not mediated by prostaglandins.
Bicuculline-sensitive GABA receptors in rat ovary.
Biochemical and Immunochemical Studies on the GABAergic System in the Rat Fallopian Tube and Ovary
The findings suggest an extrinsic GABAergic innervation in the rat Fallopian tube but not in the ovary, which is in contrast with the enzyme present in ovaries, liver, anterior pituitary, and kidney.
Higher GABA Concentrations in Fallopian Tube Than in Brain of the Rat
It has been demonstrated for the first time that a peripheral organ, i.e. fallopian tube, contained higher GABA concentrations than the CNS.
Presence of γ‐Aminobutyric Acid in Rat Ovary
It is concluded that the synthesis of the GABA is intragonadal and probably of metabolic importance.