Effect of lithium and amiloride on collecting tubule transport enzymes.

  title={Effect of lithium and amiloride on collecting tubule transport enzymes.},
  author={Eugene Dafnis and Neil A. Kurtzman and Sandra Sabatini},
  journal={The Journal of pharmacology and experimental therapeutics},
  volume={261 2},
In humans and animals, the administration of Li or amiloride results in a defect in urinary acidification. Both agents are thought to cause this by a voltage-dependent mechanism in the distal nephron. This study was designed to determine the effects of chronic Li and amiloride administration on the two main transport enzymes in rat nephron collecting tubule, the Na-K-adenosine triphosphatase (ATPase) and the H(+)-ATPase. We also examined the effects of both agents on these enzymes in vitro… CONTINUE READING


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