Effect of liposomes sensitized with methotrexate-gamma-dimyristoylphosphatidylethanolamine on cells that are resistant to methotrexate.

@article{Kinsky1986EffectOL,
  title={Effect of liposomes sensitized with methotrexate-gamma-dimyristoylphosphatidylethanolamine on cells that are resistant to methotrexate.},
  author={S. Kinsky and K. Hashimoto and J. Loader and M. S. Knight and D. Fernandes},
  journal={Biochimica et biophysica acta},
  year={1986},
  volume={885 2},
  pages={
          129-35
        }
}
  • S. Kinsky, K. Hashimoto, +2 authors D. Fernandes
  • Published 1986
  • Chemistry, Medicine
  • Biochimica et biophysica acta
  • This study compares the ability of methotrexate and liposomes, in which the drug is anchored to the lipid bilayers via methotrexate-gamma-dimyristoylphosphatidylethanolamine, to inhibit proliferation of human leukemic cells (CEM/O) and cells derived from this line that are resistant to methotrexate because of either a defective transport system (CEM/MTX cells) or elevated levels of dihydrofolate reductase (CEM/R1 cells). Whereas CEM/O and CEM/MTX cells show a 120-fold difference in their… CONTINUE READING
    Chemistry and biological activity of antifolates.
    • 38

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