Effect of liposomes sensitized with methotrexate-gamma-dimyristoylphosphatidylethanolamine on cells that are resistant to methotrexate.

@article{Kinsky1986EffectOL,
  title={Effect of liposomes sensitized with methotrexate-gamma-dimyristoylphosphatidylethanolamine on cells that are resistant to methotrexate.},
  author={Stephen C. Kinsky and K Hashimoto and Joan E. Loader and M. Knight and Daniel J. Fernandes},
  journal={Biochimica et biophysica acta},
  year={1986},
  volume={885 2},
  pages={
          129-35
        }
}
12 Citations
Methotrexate interaction with a lipid membrane model of DPPC
Dipalmitoylphosphatidylcholine (DPPC) liposomes were employed as membrane models for the investigation of the interaction occurring between methotrexate (MTX) and bilayer lipid matrix. Liposomes were
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In vitro cytotoxicity studies of free and liposomal drugs against L1210 cells showed changes in both directions after liposome entrapment, thus suggesting that Liposome Entrapment may alter drug cellular uptake or may result in chemical modifications of the entrapped drug.
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The changes in drug bioavailability and biodistribution associated with liposome incorporation have been exploited to alter drug toxicity and enhance drug targeting.
Binding of liposomes to human bladder tumor epithelial cell lines: implications for an intravesical drug delivery system for the treatment of bladder cancer.
TLDR
Data suggest that targeting of drugs to superficial bladder cancer can be achieved by the intravesical administration of PC/PS MLV, which appeared to be specific to tumor cells.
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References

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Molecular and karyological analysis of methotrexate-resistant and -sensitive human leukemic CCRF-CEM cells.
TLDR
The development of resistance to methotrexate (75-fold) was associated with a 20-fold increase of dihydrofolate reductase activity, and an elongated marker chromosome containing a homogeneous staining region not present in the parent line was revealed.