Effect of liposome-encapsulated clodronate pretreatment on synthetic vector-mediated gene expression in mice

Abstract

One of the main limitations for the use of synthetic vectors in gene therapy is their relatively low in vivo efficiency when compared with viral vectors. Here, we describe a pretreatment protocol with liposome-encapsulated clodronate in mice by which gene expression levels of a luciferase reporter gene could be increased up to nine-fold in the lung, after… (More)
DOI: 10.1038/sj.gt.3300826

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