Effect of lipoic acid on cyclophosphamide-induced diabetes and insulitis in non-obese diabetic mice.

@article{Faust1994EffectOL,
  title={Effect of lipoic acid on cyclophosphamide-induced diabetes and insulitis in non-obese diabetic mice.},
  author={Andr{\'e}a Faust and Volker Burkart and Heather Ulrich and C. H. Weischer and Hubert Kolb},
  journal={International journal of immunopharmacology},
  year={1994},
  volume={16 1},
  pages={61-6}
}
In an animal model of type I diabetes, the non-obese diabetic (NOD) mouse, the influence of the antioxidant lipoic acid (LA) on the development of diabetes was investigated. Acceleration of diabetes development with cyclophosphamide (CY) resulted in 60% diabetic animals with severely infiltrated islets within 1-3 weeks. Daily administration of lipoic acid for 20 or 30 days around cyclophosphamide treatment suppressed the incidence of diabetes to 30% (P < 0.05) and 33%, respectively… CONTINUE READING
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