[Effect of ligustrazine injection on vascular endothelial cell of the patients with arteriosclerosis obliterans].

Abstract

OBJECTIVE To study the effect of ligustrazine injection (LI) on vascular endothelial cell of the patients with arteriosclerosis obliterans (ASO) and explore the new pathway of investigating effective vascular protective agents in Chinese medicinal herbs. METHODS Forty-six patients with ASO in the LI group treated by LI were observed, their circulating endothelial cells (CEC) were detected quantitatively before and after treatment. The results were compared with the CEC of 53 cases of healthy persons (control group) in the same period. RESULTS In the LI group, the immediate cure rate was 45.7% (21 cases), markedly effective rate 36.9% (17 cases) and the effective rate 17.4% (8 cases). The CEC of patients before treatment was 4.39 +/- 1.76/0.9 microliter, which was significantly higher than that of the healthy persons (1.53 +/- 0.42/0.9 microliter). It could be reduced after treatment, along with the improvement of symptoms and signs, to 2.43 +/- 0.87/0.9 microliter, P < 0.01. CONCLUSION LI in treating ASO not only displays extraordinary effect, but also has good effect in curing the damage of endothelial cells.

Cite this paper

@article{Li2000EffectOL, title={[Effect of ligustrazine injection on vascular endothelial cell of the patients with arteriosclerosis obliterans].}, author={S Li and P Huang and Cheng Chih Liu}, journal={Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine}, year={2000}, volume={20 6}, pages={412-4} }