Effect of light on oxygen-induced retinopathy in the rat model

  title={Effect of light on oxygen-induced retinopathy in the rat model},
  author={Benedetto Ricci and D. Lepore and Mario Iossa and Alessandro Santo and Mario D'urso and Nicola Maggiano},
  journal={Documenta Ophthalmologica},
The purpose of this study was to establish whether exposure to intense lighting favors the development or aggravates experimental oxygen-induced retinopathy in the new-born rat. Five groups of Wistar rats were studied. The control group was maintained for the first 14 days of life under conditions of cyclical (12L∶12D) lighting at 12 Lx in room air. Two other groups were subjected, for the same amount of time, to semi-darkness (2 Lx; 12L∶12D), one with room air and the other with supplemental… 

Structural and functional consequences of bright light exposure on the retina of neonatal rats

Previous claims suggesting that exposure to bright light prior to eyelid opening had no measurable consequences on the retinal structure and function were reinvestigated, with the claim being that despite a non-detectable acute phase, bright light exposure prior to eyebrows opening could nonetheless yield a significant retinopathy during the chronic phase of development of LIR.

Reduction of apoptosis in ischemic retinas of two mouse models using hyperbaric oxygen treatment.

HBO treatment protects injured neuronal cells from apoptosis in mouse models of retinal ischemia and should prompt clinical trials of acute ischemic retinal damage.

Revisiting the mouse model of oxygen-induced retinopathy

The historical developments that have led to the mouse OIR model utilized today, essential concepts of OIR, limitations of the model, and a representative selection of key findings from OIR are explored, with particular emphasis on current research progress.

History of the mouse model of OIR Initial clinical observations

The historical developments that have led to the mouse OIR model utilized today, essential concepts of OIR, limitations of the model, and a representative selection of key findings from OIR are explored, with particular emphasis on current research progress.

Light exposure is not associated with retinopathy of prematurity.

  • M. Mills
  • Medicine
    Archives of ophthalmology
  • 1998
A reduction in ambient-light exposure does not alter the incidence of retinopathy of prematurity and a causal relation to hospital-nursery lighting is not established.

Difference in ischemic regulation of vascular endothelial growth factor and pigment epithelium--derived factor in brown norway and sprague dawley rats contributing to different susceptibilities to retinal neovascularization.

Observations support the idea that different regulation of angiogenic inhibitors and stimulators under ischemia are responsible for the differences in susceptibility to ischemIA-induced retinal neovascularization in SD and BN rats.

Interruption of Wnt Signaling in Müller Cells Ameliorates Ischemia-Induced Retinal Neovascularization

D disruption of β-catenin in Müller cells attenuated over-expression of inflammatory cytokines and ameliorated pericyte dropout in the retina and represents a potential therapeutic target for DR.

Early light reduction for preventing retinopathy of prematurity in very low birth weight infants.

The evidence shows that bright light is not the cause of retinopathy of prematurity and that the reduction of exposure of the retinas of premature infants to light has no effect on the incidence of the disease.



Oxygen-induced retinopathy in newborn rats: effects of prolonged normobaric and hyperbaric oxygen supplementation.

It is possible that moderate hyperbarism exerts, in the newborn rat, a protective action against the toxic effects of oxygen supplementation on immature retinal vessels.

Oxygen-induced retinopathy in newborn rats: orthograde axonal transport changes in optic pathways.

Retinal damage by light in rats.

The retina of laboratory rats is affected irreversibly by intense light applied for less than 1 hour or for up to 2 days depending upon experimental conditions, and the action spectrum of the daviaging effect approximated that of visual excitation as measured by the ERG.

Light damage in the developing retina of the albino rat: an electroretinographic study.

Electroretinographic responses were measured in rats exposed at different ages during the period of retinal development to 24 hr of bright light and then transferred to darkness for about 2 months and indicated that if the bright-light exposure was done prior to 20 days of age, the retina was resistant to the light damage, and the dark-adapted ERG responses measured later were normal.

Effect of light history on rod outer-segment membrane composition in the rat.

Retinal light-damage in albino rats: lysosomal enzymes, rhodopsin, and age.

Effects of hyperbaric, normobaric and hypobaric oxygen supplementation on retinal vessels in newborn rats: a preliminary study.

  • B. Ricci
  • Medicine
    Experimental eye research
  • 1987

Photoreceptor degeneration in albino rats: dependency on age.

Reduction in the overall thickness of the retina as a result of light exposure was not as impressive as the effect on the ONL, and photoreceptor damage apparently was not influenced by the animal's gender.