Effect of light on oxygen-induced retinopathy in the rat model

  title={Effect of light on oxygen-induced retinopathy in the rat model},
  author={Benedetto Ricci and D. Lepore and Mario Iossa and Alessandro Santo and Mario D'urso and Nicola Maggiano},
  journal={Documenta Ophthalmologica},
The purpose of this study was to establish whether exposure to intense lighting favors the development or aggravates experimental oxygen-induced retinopathy in the new-born rat. Five groups of Wistar rats were studied. The control group was maintained for the first 14 days of life under conditions of cyclical (12L∶12D) lighting at 12 Lx in room air. Two other groups were subjected, for the same amount of time, to semi-darkness (2 Lx; 12L∶12D), one with room air and the other with supplemental… 
Reduction of apoptosis in ischemic retinas of two mouse models using hyperbaric oxygen treatment.
HBO treatment protects injured neuronal cells from apoptosis in mouse models of retinal ischemia and should prompt clinical trials of acute ischemic retinal damage.
Light exposure is not associated with retinopathy of prematurity.
  • M. Mills
  • Medicine
    Archives of ophthalmology
  • 1998
A reduction in ambient-light exposure does not alter the incidence of retinopathy of prematurity and a causal relation to hospital-nursery lighting is not established.
Difference in ischemic regulation of vascular endothelial growth factor and pigment epithelium--derived factor in brown norway and sprague dawley rats contributing to different susceptibilities to retinal neovascularization.
Observations support the idea that different regulation of angiogenic inhibitors and stimulators under ischemia are responsible for the differences in susceptibility to ischemIA-induced retinal neovascularization in SD and BN rats.
Early light reduction for preventing retinopathy of prematurity in very low birth weight infants.
The evidence shows that bright light is not the cause of retinopathy of prematurity and that the reduction of exposure of the retinas of premature infants to light has no effect on the incidence of the disease.
Basic and Clinical Aspects
Lesion studies in rodents provided the initial evidence that the SCN are the site of a circadian pacemaker, and in vivo and in vitro studies have since shown day-night rhythms in electric activity, metabolic activity, and gene expre~sion.
History of the mouse model of OIR Initial clinical observations
The historical developments that have led to the mouse OIR model utilized today, essential concepts of OIR, limitations of the model, and a representative selection of key findings from OIR are explored, with particular emphasis on current research progress.
Revisiting the mouse model of oxygen-induced retinopathy
The historical developments that have led to the mouse OIR model utilized today, essential concepts of OIR, limitations of the model, and a representative selection of key findings from OIR are explored, with particular emphasis on current research progress.
Interruption of Wnt Signaling in Müller Cells Ameliorates Ischemia-Induced Retinal Neovascularization
D disruption of β-catenin in Müller cells attenuated over-expression of inflammatory cytokines and ameliorated pericyte dropout in the retina and represents a potential therapeutic target for DR.
Structural and functional consequences of bright light exposure on the retina of neonatal rats
Previous claims suggesting that exposure to bright light prior to eyelid opening had no measurable consequences on the retinal structure and function were reinvestigated, with the claim being that despite a non-detectable acute phase, bright light exposure prior to eyebrows opening could nonetheless yield a significant retinopathy during the chronic phase of development of LIR.


Retinal cyclic light damage threshold for albino rats.
A reasonable estimate for the threshold cyclic light intensity which produces damage to retinas of albino rats raised under 6 lux lies between 130 and 270 lux, or approximately 1.3 log units above the light intensity under which the animals were raised.
Oxygen-induced retinopathy in newborn rats: orthograde axonal transport changes in optic pathways.
Retinal damage by light in rats.
The retina of laboratory rats is affected irreversibly by intense light applied for less than 1 hour or for up to 2 days depending upon experimental conditions, and the action spectrum of the daviaging effect approximated that of visual excitation as measured by the ERG.
Effect of light history on rod outer-segment membrane composition in the rat.
Retinal light-damage in albino rats: lysosomal enzymes, rhodopsin, and age.
Effects of hyperbaric, normobaric and hypobaric oxygen supplementation on retinal vessels in newborn rats: a preliminary study.
  • B. Ricci
  • Medicine
    Experimental eye research
  • 1987
Retinal oxygen tension is higher in light than dark.
The oxygen tension at the inner retinal surface in rabbits was measured with intraocular polarographic electrodes and it was found that breathing 100% oxygen elevates the preretinal oxygen tension to 190 +/- 72 mm Hg (mean +/- 1 SD, n = 4) in light.
Effect of bright light in the hospital nursery on the incidence of retinopathy of prematurity.
It is concluded that the high level of ambient illumination commonly found in the hospital nursery may be one factor contributing to retinopathy of prematurity and that safety standards with regard to current lighting practices should be reassessed.