Effect of light chain V region duplication on IgG oligomerization and in vivo efficacy.

@article{Shuford1991EffectOL,
  title={Effect of light chain V region duplication on IgG oligomerization and in vivo efficacy.},
  author={Walt Shuford and Howard V. Raff and John W Finley and James M Esselstyn and L. J. Harris},
  journal={Science},
  year={1991},
  volume={252 5006},
  pages={724-7}
}
A human immunoglobulin G1 (IgG1) antibody oligomer was isolated from a transfected myeloma cell line that produced a monoclonal antibody to group B streptococci. Compared to the IgG1 monomer, the oligomer was significantly more effective at protecting neonatal rats from infection in vivo. The oligomer was also shown to cross the placenta and to be stable in neonatal rats. Immunochemical analysis and complementary DNA sequencing showed that the transfected cell line produced two distinct kappa… CONTINUE READING