Effect of levothyroxine on cardiac function and structure in subclinical hypothyroidism: a double blind, placebo-controlled study.

@article{Monzani2001EffectOL,
  title={Effect of levothyroxine on cardiac function and structure in subclinical hypothyroidism: a double blind, placebo-controlled study.},
  author={Fabio Monzani and Vitantonio Di Bello and Nadia Caraccio and A. B. Libreros Bertini and Davide Giorgi and Costantino Giusti and Ele Ferrannini},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2001},
  volume={86 3},
  pages={1110-5}
}
Subclinical hypothyroidism (sHT) affects 5-15% of the general population; however, the need of lifelong L-T(4) therapy is still controversial. As myocardium is a main target of thyroid hormone action, we investigated whether sHT induces cardiovascular alterations. Twenty sHT patients were randomly assigned to receive placebo or L-T(4) therapy and were followed for 1 yr. Twenty sex- and age-matched normal subjects served as controls. Doppler echocardiography and videodensitometric analysis were… CONTINUE READING
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