Effect of levetiracetam on human corticospinal excitability.

  title={Effect of levetiracetam on human corticospinal excitability.},
  author={Young Hwan Sohn and Alain Kaelin-Lang and Han Young Jung and Mark Hallett},
  volume={57 5},
OBJECTIVE To investigate whether levetiracetam (LTC) alters corticospinal excitability in humans. BACKGROUND Although the antiepileptic activity of LTC is well recognized, its mechanism of action has yet to be determined. Transcranial magnetic stimulation (TMS) has been used to investigate the pharmacologic effects of various antiepileptic drugs on human corticospinal excitability. METHODS The authors performed TMS before and after double-blind administration of 3000 mg LTC or placebo in… CONTINUE READING