Effect of leukocyte depletion on the function of the postobstructed kidney in the rat.

@article{Harris1989EffectOL,
  title={Effect of leukocyte depletion on the function of the postobstructed kidney in the rat.},
  author={Kevin P G Harris and George F. Schreiner and Saulo Klahr},
  journal={Kidney international},
  year={1989},
  volume={36 2},
  pages={210-5}
}
We have observed an influx of leukocytes, predominantly macrophages, into the cortex and medulla of the kidney following ureteral obstruction. To examine the potential contribution of these infiltrating cells to the decrease in GFR and RPF that occurs following ureteral obstruction, 16 male Lewis rats (wt 246.4 +/- 4.0 g) were studied in the awake state three hours after unilateral release of 24 hours of bilateral ureteral obstruction (BUO). Eight rats were not irradiated, and eight rats… CONTINUE READING

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