Effect of leukemia inhibitory factor on embryonic stem cell differentiation: implications for supporting neuronal differentiation

@article{He2006EffectOL,
  title={Effect of leukemia inhibitory factor on embryonic stem cell differentiation: implications for supporting neuronal differentiation},
  author={Zhao He and Jing-jing Li and Chang-hong Zhen and Lin-ying Feng and Xiao-yan Ding},
  journal={Acta Pharmacologica Sinica},
  year={2006},
  volume={27},
  pages={80-90}
}
AbstractAim:Leukemia inhibitory factor (LIF), a pleiotropic cytokine, has been used extensively in the maintenance of mouse embryonic stem cell pluripotency. In this current work, we examined the effect of the LIF signaling pathway in embryonic stem (ES) cell differentiation to a neural fate.Methods:In the presence of LIF (1000 U/mL), the production of neuronal cells derived from embryoid bodies (EB) was tested under various culture conditions. Inhibition of the LIF pathway was examined with… CONTINUE READING

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