Effect of lesions of the anteroventral third ventricle (AV3V) on the development of hypertension in spontaneously hypertensive rats.

@article{Gordon1982EffectOL,
  title={Effect of lesions of the anteroventral third ventricle (AV3V) on the development of hypertension in spontaneously hypertensive rats.},
  author={Frank J Gordon and Joseph R. Haywood and Michael J. Brody and Alan Kim Johnson},
  journal={Hypertension},
  year={1982},
  volume={4 3},
  pages={387-93}
}
Lesions of the anteroventral third ventricle (AV3V), an angiotensin and osmosensitive region of the anterior hypothalamus, prevent or abort hypertension in a number of rat models. To determine if AV3V lesions alter hypertension in spontaneously hypertensive rats (SHR), lesions and control sham lesions were made in young SHR at 28 days of age. AV3V lesions had no effect on the development of hypertension in SHR. However, lesioned rats demonstrated significantly reduced pressor responses to… CONTINUE READING