Effect of lesions in the ventral noradrenergic tract produced by microinjection of 6-hydroxydopamine on gonadotropin release in the rat.

  title={Effect of lesions in the ventral noradrenergic tract produced by microinjection of 6-hydroxydopamine on gonadotropin release in the rat.},
  author={J. V. Martinovi{\'c} and Samuel M. Mccann},
  volume={100 4},
Noradrenergic innervation to the hypothalamus is provided principally by the ventral noradrenergic tract (VNAT) which carries the axons of noradrenergic neurons whose cell bodies lie in the brain stem. To determine the importance of the VNAT in the stimulation of LH release induced by progesterone in ovariectomized, estrogen-primed rats, 6-hydroxydopamine (6-OHDA), an agent which selectively destroys catecholaninergic neurons, was microinjected bilaterally into this tract, 2 days after priming… 
Effects of chemical lesion of the ventral noradrenergic bundle or of the medial preoptic area on preovulatory LH release in rats
It is concluded that the availability of NE in the MPO is an important factor in determining the hight of the preovulatory LH surge.
Lateral hypothalamic mediation of midbrain catecholaminergic influences on preovulatory surges of serum gonadotropin and prolactin in female rats.
The results suggest that the lateral hypothalamus plays an important role in the control of preovulatory surges of serum gonadotropin and PRL by mediating the midbrain catecholaminergic innervation of the preoptic-hypothalamic area.
Hypothalamic and raphe serotonergic systems in ovulation control.
  • D. Meyer
  • Biology, Medicine
  • 1978
The role of hypothalamic and midbrain serotonergic systems in the control of ovulation in the rat has been investigated using 5,7-dihydroxytryptamine lesioning in conjunction with desmethylimipramine pretreatment and a general feature of every case of inhibited ovulation was the significant decrease in uptake of serotonin in the SNR, indicating destruction ofserotonergic inputs to this region.
Opioid modulation of the response of preoptic neurones to stimulation of the ventral noradrenergic tract in female rats.
It is demonstrated that opioid peptides modulate the neural inputs to the medial preoptic area arising from the nucleus arcuatus and the ventral noradrenergic tract and thereby influence the neural circuitry controlling the secretion of luteinizing hormone.
Effect of ventral noradrenergic bundle lesions on concentrations of monoamine neurotransmitters and metabolites in several discrete areas of the rat brain
The results indicate that the NE innervation to the hypothalamus is extensive and that NE in the VMN may not be derived from the VNB.
Opioid peptides inhibit the release of noradrenaline from slices of rat medial preoptic area
The experiments provide direct evidence that brain opioids modulate the noradrenergic input to MPOA neurones and support the hypothesis that this may be one mechanism for the regulation of LH secretion.
Neural loci involved in naloxone-induced luteinizing hormone release: effects of a norepinephrine synthesis inhibitor.
Placement of implants, containing naloxone crystals on day 2 at 1200 h unilaterally at sites previously known to influence LH release and/or innervated by NE neurons, such as locus coeruleus, medial raphae nucleus, amygdaloid complex, medial lemniscus, septal-diagonal band of Broca, or ventro-dorsomedial hypothalamus failed to stimulate LH release.