Effect of lentivirus encoding HIV-1 Nef-U3 shRNA on the function of HIV-specific memory CD4(+) T cells in patients with chronic HIV-1 infection.

@article{Yamamoto2009EffectOL,
  title={Effect of lentivirus encoding HIV-1 Nef-U3 shRNA on the function of HIV-specific memory CD4(+) T cells in patients with chronic HIV-1 infection.},
  author={Takuya Yamamoto and Assia Samri and Anne-genevi{\`e}ve Marcelin and Yu-ya Mitsuki and Calvez Vincent and Brigitte Autran and Yasuko Tsunetsugu-Yokota},
  journal={AIDS},
  year={2009},
  volume={23 17},
  pages={2265-75}
}
OBJECTIVE To determine whether HIV-1-specific CD4 T cells with proliferative capacity are eliminated or functionally defective because of HIV-1 reactivation. DESIGN The loss of proliferative capacity by HIV-1-specific CD4 T cells compromises the host's ability to maintain protective immunity against HIV-1 and is a hallmark of disease progression. We used a recombinant lentivirus encoding an HIV-specific short hairpin (sh)RNA (Lenti shNef366) with known HIV-inhibitory activity to analyze the… CONTINUE READING